Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.

@article{Vaur2012Pds5PC,
  title={Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.},
  author={Sabine Vaur and Am{\'e}lie Feytout and St{\'e}phanie Vazquez and Jean-Paul Javerzat},
  journal={EMBO reports},
  year={2012},
  volume={13 7},
  pages={645-52}
}
Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a stable cohesin interaction with replicated chromosomes. The latter requires Eso1 only in the presence of Wapl, indicating that cohesin… CONTINUE READING

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