PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis.


Lipoic acid is a covalently-bound enzyme cofactor required for central metabolism all three domains of life. In the last 20 years the pathway of lipoic acid synthesis and metabolism has been established in Escherichia coli. Expression of the genes of the lipoic acid biosynthesis pathway was believed to be constitutive. However, in 2010 Kaleta and coworkers… (More)
DOI: 10.1016/j.resmic.2014.04.005