Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice.

@article{Vishvanath2016PdgfrMP,
  title={Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice.},
  author={Lavanya Vishvanath and Karen A. MacPherson and Chelsea Hepler and Qiong A. Wang and Mengle Shao and Stephen B. Spurgin and Margaret Y Wang and Christine M. Kusminski and Thomas S. Morley and Rana K Gupta},
  journal={Cell metabolism},
  year={2016},
  volume={23 2},
  pages={
          350-9
        }
}
The expansion of white adipose tissue (WAT) in obesity involves de novo differentiation of new adipocytes; however, the cellular origin of these cells remains unclear. Here, we utilize Zfp423(GFP) reporter mice to characterize adipose mural (Pdgfrβ(+)) cells with varying levels of the preadipocyte commitment factor Zfp423. We find that adipose tissue contains distinct mural populations, with levels of Zfp423 distinguishing adipogenic from inflammatory-like mural cells. Using our "MuralChaser… CONTINUE READING
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