Pd(0)/PR3-catalyzed intermolecular arylation of sp3 C-H bonds.

Abstract

Pd(0)-catalyzed intermolecular arylation of sp(3) C-H bonds has been achieved using PR(3)/ArI. This protocol can be used to arylate a variety of aliphatic carboxylic acid derivatives, including a number of bioactive drug molecules. The use of fluorinated aryl iodides also allows for the introduction of fluorine into a molecule of interest. 
DOI: 10.1021/ja903573p

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