Pcf11 orchestrates transcription termination pathways in yeast.

  title={Pcf11 orchestrates transcription termination pathways in yeast.},
  author={Pawel Grzechnik and Michal Gdula and Nicholas Proudfoot},
  journal={Genes & development},
  volume={29 8},
In Saccharomyces cerevisiae, short noncoding RNA (ncRNA) generated by RNA polymerase II (Pol II) are terminated by the NRD complex consisting of Nrd1, Nab3, and Sen1. We now show that Pcf11, a component of the cleavage and polyadenylation complex (CPAC), is also generally required for NRD-dependent transcription termination through the action of its C-terminal domain (CTD)-interacting domain (CID). Pcf11 localizes downstream from Nrd1 on NRD terminators, and its recruitment depends on Nrd1… CONTINUE READING
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