Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.

@article{Bodai2012PcafMP,
  title={Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.},
  author={L{\'a}szl{\'o} Bodai and Judit Pallos and Leslie M. Thompson and J. Lawrence Marsh},
  journal={Neuro-degenerative diseases},
  year={2012},
  volume={9 2},
  pages={104-6}
}
Huntingtin peptides with elongated polyglutamine domains, the root causes of Huntington's disease, hinder histone acetylation, which leads to transcriptional dysregulation. However, the range of acetyltransferases interacting with mutant Huntingtin has not been systematically evaluated. We used genetic interaction tests in Drosophila to determine whether specific acetyltransferases belonging to distinct protein families influence polyglutamine pathology. We found that flies expressing a mutant… CONTINUE READING

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