Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors.

  title={Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors.},
  author={Francesca Ficara and Laura Crisafulli and ChenWei Lin and Masayuki Iwasaki and Kevin S. Smith and Luca Zammataro and Michael L. Cleary},
  journal={Journal of cell science},
  volume={126 Pt 14},
The capacity of the hematopoietic system to promptly respond to peripheral demands relies on adequate pools of progenitors able to transiently proliferate and differentiate in a regulated manner. However, little is known about factors that may restrain progenitor maturation to maintain their reservoirs. Conditional knockout mice for the Pbx1 proto-oncogene have a significant reduction in lineage-restricted progenitors in addition to a profound defect in hematopoietic stem cell (HSC) self… CONTINUE READING
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