Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.

@article{Ficara2008Pbx1RS,
  title={Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence.},
  author={Francesca Ficara and Mark J. Murphy and Min Zhong Lin and Michael L. Cleary},
  journal={Cell stem cell},
  year={2008},
  volume={2 5},
  pages={484-96}
}
Self-renewal is a defining characteristic of stem cells; however, the molecular pathways underlying its regulation are poorly understood. Here, we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in the hematopoietic compartment results in a progressive loss of long-term hematopoietic stem cells (LT-HSCs) that is associated with concomitant reduction in their quiescence, leading to a defect in the maintenance of self-renewal as assessed by serial transplantation… CONTINUE READING
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