Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential.

Abstract

Skeletal muscle differentiation is initiated by the transcription factor MyoD, which binds directly to the regulatory regions of genes expressed during skeletal muscle differentiation and initiates chromatin remodeling at specific promoters. It is not known, however, how MyoD initially recognizes its binding site in a chromatin context. Here we show that… (More)

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