Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

@article{Stankunas2008PbxMeisDD,
  title={Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.},
  author={Kryn Stankunas and Ching Shang and Karen Y. Twu and Shih-chu Kao and Nancy A. Jenkins and Neal G. Copeland and Mrinmoy Sanyal and Licia Selleri and Michael L. Cleary and Ching-Pin Chang},
  journal={Circulation research},
  year={2008},
  volume={103 7},
  pages={
          702-9
        }
}

• Kryn Stankunas, Ching Shang, +7 authors Ching-Pin Chang
• Published 2008 in Circulation research
• DOI:10.1161/CIRCRESAHA.108.175489

Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis resulting from environmental and genetic interactions that determine penetrance and expressivity within a genetically predisposed family. Recent evidence suggests that genetic contributions have been significantly underestimated. However, single gene defects occur only in a minority of cases, and multigenetic causes of congenital heart diseases have not been fully demonstrated. Here, we show that… CONTINUE READING

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