Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

  title={Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.},
  author={Kryn Stankunas and Ching Shang and Karen Y. Twu and Shih-chu Kao and Nancy A. Jenkins and Neal G. Copeland and Mrinmoy Sanyal and Licia Selleri and Michael L. Cleary and Ching-Pin Chang},
  journal={Circulation research},
  volume={103 7},
Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis resulting from environmental and genetic interactions that determine penetrance and expressivity within a genetically predisposed family. Recent evidence suggests that genetic contributions have been significantly underestimated. However, single gene defects occur only in a minority of cases, and multigenetic causes of congenital heart diseases have not been fully demonstrated. Here, we show that… CONTINUE READING
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Cardiac Development

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