Pazopanib for the treatment of renal cancer.

  title={Pazopanib for the treatment of renal cancer.},
  author={Mhd Yaser Al-Marrawi and Brian I. Rini},
  journal={Expert opinion on pharmacotherapy},
  volume={12 7},
INTRODUCTION Dramatic advances in the care of patients with advanced renal cell carcinoma (RCC) have occurred over the last 10 years. Insights into the molecular pathogenesis of this disease have elucidated the importance of signaling cascades related to angiogenesis in the management of RCC. Pazopanib is a novel, small-molecule tyrosine kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3; platelet-derived growth factor receptors (PDGFR)-α and… CONTINUE READING


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