Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.

@article{Javidnia2017PazopanibRP,
  title={Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.},
  author={Monica Javidnia and Michaeline L. Hebron and Yue Xin and Nikolas G Kinney and Charbel Moussa},
  journal={Journal of Alzheimer's disease : JAD},
  year={2017},
  volume={60 2},
  pages={461-481}
}
Hyperphosphorylation and aggregation of tau protein is a critical factor in many neurodegenerative diseases. These diseases are increasing in prevalence, and there are currently no cures. Previous work from our group and others has shown that tyrosine kinase inhibitors (TKIs) can stimulate autophagy, decrease pathological proteins, and improve symptoms in models of neurodegeneration. Here we examined the role of pazopanib in mouse models that express either human mutant P301L tau (TauP301L) or… CONTINUE READING