Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy.

@article{Mukaiyama2002Paz2A1,
  title={Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy.},
  author={Hiroyuki Mukaiyama and Masahide Oku and Misuzu Baba and Takeshi Samizo and Adam T. Hammond and Benjamin S. Glick and Nobuo Kato and Yasuyoshi Sakai},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2002},
  volume={7 1},
  pages={75-90}
}
BACKGROUND In the methylotrophic yeast Pichia pastoris, peroxisomes can be selectively degraded through direct engulfment by the vacuole in a process known as micropexophagy, but the mechanism of micropexophagy is not known. RESULTS To gain molecular insights into micropexophagy, we used fluorescence time-lapse microscopy, coupled with gene-tagging mutagenesis to isolate P. pastoris mutants defective in micropexophagy. The relevant genes have been designated PAZ genes. Morphological and… CONTINUE READING

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