Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function.

@article{Gosmain2010Pax6CT,
  title={Pax6 controls the expression of critical genes involved in pancreatic \{alpha\} cell differentiation and function.},
  author={Yvan Gosmain and Eric Marthinet and Claire Cheyssac and Audrey Gu{\'e}rardel and Aline Mamin and Liora S. Katz and Karim Bouzakri and Jacques Philippe},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 43},
  pages={33381-93}
}
The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an essential role in glucose homeostasis. Indeed, mutations of Pax6 are associated with diabetic phenotype. Importantly, homozygous mutant mice for Pax6 are characterized by markedly decreased β and δ cells and absent α cells. To better understand the critical role that Pax6 exerts in glucagon-producing cells, we developed a model of primary rat α cells. To study the transcriptional network of Pax6… CONTINUE READING

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