Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation.

@article{Olaopa2011Pax3IE,
  title={Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation.},
  author={Michael A Olaopa and Hong-ming Zhou and Paige Snider and Jian You Wang and Robert J. Schwartz and Anne M. Moon and Simon J. Conway},
  journal={Developmental biology},
  year={2011},
  volume={356 2},
  pages={
          308-22
        }
}
Systemic loss-of-function studies have demonstrated that Pax3 transcription factor expression is essential for dorsal neural tube, early neural crest and muscle cell lineage morphogenesis. Cardiac neural crest cells participate in both remodeling of the pharyngeal arch arteries and outflow tract septation during heart development, but the lineage specific role of Pax3 in neural crest function has not yet been determined. To gain insight into the requirement of Pax3 within the neural crest, we… CONTINUE READING

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