Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells

@article{Relaix2006Pax3AP,
  title={Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells},
  author={Fr{\'e}d{\'e}ric Relaix and Didier Montarras and St{\'e}phane Zaffran and Barbara Gayraud-Morel and Didier Rocancourt and Shahragim Tajbakhsh and Ahmed Mansouri and Ana Cumano and M. Buckingham},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={172},
  pages={91 - 102}
}
The growth and repair of skeletal muscle after birth depends on satellite cells that are characterized by the expression of Pax7. We show that Pax3, the paralogue of Pax7, is also present in both quiescent and activated satellite cells in many skeletal muscles. Dominant-negative forms of both Pax3 and -7 repress MyoD, but do not interfere with the expression of the other myogenic determination factor, Myf5, which, together with Pax3/7, regulates the myogenic differentiation of these cells. In… CONTINUE READING
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