Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance.

@article{Cai2005Pax2EO,
  title={Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance.},
  author={Qi Cai and Natalia I. Dmitrieva and Joan D. Ferraris and Heddwen L. Brooks and Bas W M van Balkom and Maurice Burg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 2},
  pages={503-8}
}
Pax2 is a transcription factor that is crucial for kidney development, and it is also expressed in the normal adult kidney, where its physiological function is unknown. In the present study, we find by cDNA microarray analysis that Pax2 expression in second-passage mouse inner-medullary epithelial cells is increased by a high NaCl concentration, which is significant because NaCl levels are normally high in the inner medulla in vivo, and varies with urinary concentration. Furthermore, a high… CONTINUE READING

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