Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation

@inproceedings{Bouchard2010Pax2AP,
  title={Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation},
  author={Maxime Bouchard and Dominique de Caprona and Meinrad Busslinger and Pinxian Xu and Bernd Fritzsch},
  booktitle={BMC Developmental Biology},
  year={2010}
}
Pax2;5;8 transcription factors play diverse roles in vertebrate and invertebrate organogenesis, including the development of the inner ear. Past research has suggested various cochlear defects and some vestibular defects in Pax2 null mice but the details of the cochlear defects and the interaction with other Pax family members in ear development remain unclear. We show that Pax2;8 double null mice do not develop an ear past the otocyst stage and show little to no sensory as well as limited and… CONTINUE READING
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