Pax2, Otx2, Gbx2 and Fgf8 expression in early otic vesicle development

  title={Pax2, Otx2, Gbx2 and Fgf8 expression in early otic vesicle development},
  author={Matı́as Hidalgo-S{\'a}nchez and Rosa-Magda Alvarado-Mallart and Ignacio Santiago Alvarez},
  journal={Mechanisms of Development},
The inner ear is a suitable system to study the mechanisms involved in the specification of different functional domains during morphogenesis. Using single and double in situ hybridization (ISH) we show that three transcription factors (Otx2, Gbx2and Pax2) and a member of the fibroblast growth factor family (Fgf8) could participate in the compartmentalization of the otic vesicle and in the formation of the acoustic-vestibular ganglion. 


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Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the midbrain/hindbrain

  • M. Hidalgo-SaÂnchez, S. Millet, A. Simeone, Alvarado-Mallart, R.-M
  • domain. Mech. Dev
  • 1999
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