Pax 6 2 / 2 Mice Have a Cell Nonautonomous Defect in Nonradial Interneuron Migration

The mammalian neocortex comprises two major neuronal subtypes; interneurons derived from the ganglionic eminence (GE) and projection neurons from the cortical ventricular zone (VZ). These separate origins necessitate distinct pathways of migration. Using mouse genetics and embryonic forebrain slice culture assays, we sought to identify substrates and/or… CONTINUE READING