Pavlovian psychopharmacology: the associative basis of tolerance.

@article{Siegel2000PavlovianPT,
  title={Pavlovian psychopharmacology: the associative basis of tolerance.},
  author={Shepard Siegel and Marco A. S. Baptista and Joseph A. Kim and Robert Victor Mcdonald and Lorraine Weise-Kelly},
  journal={Experimental and clinical psychopharmacology},
  year={2000},
  volume={8 3},
  pages={
          276-93
        }
}
The Pavlovian conditioning analysis of drug tolerance emphasizes that cues present at the time of drug administration become associated with drug-induced disturbances. These disturbances elicit unconditional responses that compensate for the pharmacological perturbation. The drug-compensatory responses eventually come to be elicited by drug-paired cues. These conditional compensatory responses (CCRs) mediate tolerance by counteracting the drug effect when the drug is administered in the… CONTINUE READING

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