Pavlovian fear memory induced by activation in the anterior cingulate cortex

@article{Tang2005PavlovianFM,
  title={Pavlovian fear memory induced by activation in the anterior cingulate cortex},
  author={Jianrong Tang and Shanelle W. Ko and Hoi-Ki Ding and Chang-Shen Qiu and Amelita A. Calejesan and Min Zhuo},
  journal={Molecular Pain},
  year={2005},
  volume={1},
  pages={6 - 6}
}
Identifying higher brain central region(s) that are responsible for the unpleasantness of pain is the focus of many recent studies. Here we show that direct stimulation of the anterior cingulate cortex (ACC) in mice produced fear-like freezing responses and induced long-term fear memory, including contextual and auditory fear memory. Auditory fear memory required the activation of N-methyl-D-aspartate (NMDA) receptors in the amygdala. To test the hypothesis that neuronal activity in the ACC… CONTINUE READING