Pavlovian Heart Rate and Jaw Movement Conditioning in the Rabbit: Effects of Medial Prefrontal Lesions

@article{McLaughlin1999PavlovianHR,
  title={Pavlovian Heart Rate and Jaw Movement Conditioning in the Rabbit: Effects of Medial Prefrontal Lesions},
  author={Joselyn McLaughlin and Donald A. Powell},
  journal={Neurobiology of Learning and Memory},
  year={1999},
  volume={71},
  pages={150-166}
}
An experiment was conducted in which jaw movements (JM) and heart rate (HR) were concomitantly assessed in rabbits during simple Pavlovian conditioning. A 2-s 1200-Hz tone was the conditioned stimulus (CS) and an intraoral 1-cc pulse of 0.5 M sucrose-water solution was the unconditioned stimulus (US). Sham and medial prefrontal (mPFC)-lesioned animals received paired CS/US training with a 70- to 75-dB CS and were compared with sham- and mPFC-lesioned animals that received explicitly unpaired CS… 
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Posttraining Prefrontal Lesions Impair Jaw Movement Conditioning Performance, but Have No Effect on Accompanying Heart Rate Changes
TLDR
The role of the medial prefrontal cortex (mPFC) in regulating learned autonomic and somatomotor responses in rabbits using appetitive Pavlovian conditioning was examined and JM CRs significantly declined in both groups with mPFC lesions in comparison to the groups with sham lesions.
Characterization of the neuronal changes in the medial prefrontal cortex during jaw movement and eyeblink Pavlovian conditioning in the rabbit
Heart rate changes accompanying jaw movement Pavlovian conditioning in rabbits: Concomitant blood pressure adjustments and effects of peripheral autonomic blockade
TLDR
The results suggest that the major cardiovascular response to an appetitive stimulus, which evokes JM conditioning, consists of cardiac accelerations with the BP depressor responses playing a minimal, if any, role.
Single unit activity in the medial prefrontal cortex during pavlovian heart rate conditioning: Effects of peripheral autonomic blockade
The role of claustrum in Pavlovian heart rate conditioning in the rabbit (Oryctolagus cuniculus): anatomical, electrophysiological, and lesion studies.
TLDR
Claustral lesions diminished the magnitude of the HR-conditioned response without affecting the cardiac-orienting response to the conditioned stimulus or the cardiac's cardiac-unconditioningresponse to the unconditioned stimulus, suggesting a role for the claustrum in associative learning.
Reevaluating the role of the medial prefrontal cortex in delay eyeblink conditioning
Neurotoxic lesions of the dorsal hippocampus disrupt auditory‐cued trace heart rate (fear) conditioning in rabbits
TLDR
The classical heart rate (HR) conditioning paradigm may be ideal for in vivo electrophysiological recording studies because rabbits are easily immobilized during the testing procedure, and learning occurs during a single day of training.
C-fos activation patterns in rat prefrontal cortex during acquisition of a cued classical conditioning task
Development of a Classical Conditioning Task for Humans Examining Phasic Heart Rate Responses to Signaled Appetitive Stimuli: A Pilot Study
TLDR
Developing and pilot testing of a classical conditioning task to assess cardiac responses to appetitive stimuli and cues that reliably precede them and similar responses were observed to non-appetitive stimuli when they were preceded by the cue associated with the food images, suggesting that attentional processes were engaged by conditioned stimuli.
Medial prefrontal cortex early lesion effects on classical conditioned bradycardia
TLDR
In lesioned rabbits, baseline HR, orienting and conditioned HR responses were similar to controls, suggesting medial prefrontal cortex must be involved in the reorganization of the CB control mechanisms following early cerebellar vermal ablation.
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References

SHOWING 1-10 OF 68 REFERENCES
The effect of medial frontal cortex lesions on cardiovascular conditioned emotional responses in the rat
The effect of medial frontal cortex lesions on respiration, "freezing," and ultrasonic vocalizations during conditioned emotional responses in rats.
TLDR
These behaviors indicate a significantly altered stress response following ventral MFC lesions, implying that the MFC may be necessary for complete expression of various behavioral responses to "stressful" stimuli.
On the generality of conditioned bradycardia in rabbits: Assessment of CS and US modality
TLDR
It is suggested that HR slowing is a general phenomenon that occurs when rabbits are exposed to signals that systematically predict aversive or appetitive consequences according to a Pavlovian conditioning paradigm.
Cingulate cortex: its role in Pavlovian conditioning.
TLDR
Three experiments with New Zealand albino rabbits examined the role of anterior and posterior cingulate cortex in Pavlovian conditioning and cingulates involvement in the mediation of the cardiovascular component of a response pattern related to stimulus processing revealed effective sites for eliciting heart rate and blood pressure changes.
Single-unit activity in the dorsomedial prefrontal cortex during the expression of discriminative bradycardia in rabbits
Peripheral autonomic mechanisms and Pavlovian conditioning in the rabbit (Oryctolagus cuniculus).
TLDR
The conditioning data are consistent with the Laceys' peripheral afferent feedback hypothesis of autonomic-somatic relations and the administration of 6-hydroxydopamine produced an impairment of the HR response early and late during acquisition but had no effect on EB conditioning.
Amygdala central nucleus lesions: Effect on heart rate conditioning in the rabbit
A comparison of two model systems of associative learning: heart rate and eyeblink conditioning in the rabbit.
TLDR
Data indicate that these two model systems of mammalian learning (based on heart period and eyeblink responses) show quite different acquisition functions, and it is significant that heart rate slowing always accompanied the eyeblink conditioned responses, even though increases in general electromyographic activity as well as eyeb link conditioned responses were simultaneously observed during CS presentation.
Hippocampal plasticity during jaw movement conditioning in the rabbit
Multiple- and single-unit activity in area 32 (prelimbic region) of the medial prefrontal cortex during Pavlovian heart rate conditioning in rabbits.
TLDR
Findings suggest that some cells in the prelimbic region may code the absence of aversive stimulation, that is, a period of relative "safety" during classical conditioning.
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