Paving the Axonal Highway: From Stem Cells to Myelin Repair

@article{Peru2008PavingTA,
  title={Paving the Axonal Highway: From Stem Cells to Myelin Repair},
  author={Raniero L. Peru and Nicole Mandrycky and Brahim Nait-Oumesmar and Qing Richard Lu},
  journal={Stem Cell Reviews},
  year={2008},
  volume={4},
  pages={304-318}
}
Multiple sclerosis (MS), a demyelinating disorder of the central nervous system (CNS), remains among the most prominent and devastating diseases in contemporary neurology. Despite remarkable advances in anti-inflammatory therapies, the inefficiency or failure of myelin-forming oligodendrocytes to remyelinate axons and preserve axonal integrity remains a major impediment for the repair of MS lesions. To this end, the enhancement of remyelination through endogenous and exogenous repair mechanisms… CONTINUE READING

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