Pausing of simian virus 40 DNA replication fork movement in vivo by (dG-dA)n.(dT-dC)n tracts.

Abstract

We have earlier demonstrated that a sequence bordering an amplified DNA segment and containing the unusual sequence (dG-dA)n.(dT-dC)n could slow replication fork movement [Rao et al., Nucleic Acids Res. 16 (1988) 8077-8094]. This was done by cloning the unusual sequence in simian virus 40 (SV40) and following the rate of incorporation of radioactively… (More)

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