Pause transfer: A topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation

@article{Chuck1992PauseTA,
  title={Pause transfer: A topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation},
  author={Steven L. Chuck and Vishwanath R. Lingappa},
  journal={Cell},
  year={1992},
  volume={68},
  pages={9-21}
}
Previously, we described the stepwise translocation of a large amino-terminal fragment of apolipoprotein B (apo B15) in which the nascent secretory chain translocates through a series of distinct, nonintegrated transmembrane intermediates with large domains exposed to the cytoplasm. Thus, apo B15 appears to stop and restart translocation at several points. We have identified a sequence of amino acids in apo B15 that confers this behavior on a heterologous chimeric protein. In addition, we… CONTINUE READING

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