Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts.

@article{Pandrea2006PaucityOC,
  title={Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts.},
  author={Ivona V. Pandrea and Cristian Apetrei and Shari N. Gordon and Joseph Barbercheck and Jason Dufour and Rudolf P. Bohm and B. 13. Sumpter and P. Deville Roques and Preston A Marx and Vanessa M Hirsch and Amitinder Kaur and Andrew A Lackner and Ronald S Veazey and Guido Silvestri},
  journal={Blood},
  year={2006},
  volume={109 3},
  pages={
          1069-76
        }
}
In contrast to lentiviral infections of humans and macaques, simian immunodeficiency virus (SIV) infection of natural hosts is nonpathogenic despite high levels of viral replication. However, the mechanisms underlying this absence of disease are unknown. Here we report that natural hosts for SIV infection express remarkably low levels of CCR5 on CD4+ T cells isolated from blood, lymph nodes, and mucosal tissues. Given that this immunologic feature is found in 5 different species of natural SIV… CONTINUE READING

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