Patz1 regulates embryonic stem cell identity.

  title={Patz1 regulates embryonic stem cell identity.},
  author={Jin Rong Ow and Hui Ma and Angela Jean and Ziyi Goh and Yun Hwa Lee and Yew Mei Chong and Richie Soong and Xin-yuan Fu and Henry Yang and Qiang Wu},
  journal={Stem cells and development},
  volume={23 10},
Embryonic stem cells (ESCs) derived from the inner cell mass (ICM) of blastocysts are pluripotent. Pluripotency is maintained by a transcriptional network in which Oct4 and Nanog are master regulators. Notably, several zinc finger transcription factors have important roles in this network. Patz1, a BTB/POZ-domain-containing zinc finger protein, is expressed at higher levels in the ICM relative to the trophectoderm. However, its function in pluripotency has been poorly studied. Here, we show… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…