Patz1 regulates embryonic stem cell identity.

@article{Ow2014Patz1RE,
  title={Patz1 regulates embryonic stem cell identity.},
  author={Jin Rong Ow and Hui Ma and Angela Jean and Ziyi Goh and Yun Hwa Lee and Yew Mei Chong and Richie Soong and Xin-yuan Fu and Henry Yang and Qiang Wu},
  journal={Stem cells and development},
  year={2014},
  volume={23 10},
  pages={1062-73}
}
Embryonic stem cells (ESCs) derived from the inner cell mass (ICM) of blastocysts are pluripotent. Pluripotency is maintained by a transcriptional network in which Oct4 and Nanog are master regulators. Notably, several zinc finger transcription factors have important roles in this network. Patz1, a BTB/POZ-domain-containing zinc finger protein, is expressed at higher levels in the ICM relative to the trophectoderm. However, its function in pluripotency has been poorly studied. Here, we show… CONTINUE READING

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