Patulin produced by an Aspergillus clavatus isolated from feed containing malting residues associated with a lethal neurotoxicosis in cattle

Abstract

A severe neurotoxicosis, comprising tremors, ataxia, paresis, recumbency and death, occurred simultaneously among several herds of beef cattle in the region of Flanders (Belgium). After a first multi-toxin screening of some suspected diet elements, verruculogen was detected in a sample of a common feed ingredient. However, when the first animal necropsies revealed serious nervous lesions, including neuronal degeneration of the central nervous system and axonal degeneration in the peripheral nervous system, further investigations focused on fungal isolation. As expected from the pathological lesions, Aspergillus clavatus was found to be the dominant fungal species in a sample of compacted fodder, containing malting residues, consumed by all the affected herds. The isolated fungus appeared to produce patulin in culture medium. Traces of patulin were also detected in the fodder. These findings and their possible role in the intoxication are discussed.

DOI: 10.1007/s11046-005-2877-x

3 Figures and Tables

Statistics

02040602008200920102011201220132014201520162017
Citations per Year

103 Citations

Semantic Scholar estimates that this publication has 103 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{SabaterVilar2004PatulinPB, title={Patulin produced by an Aspergillus clavatus isolated from feed containing malting residues associated with a lethal neurotoxicosis in cattle}, author={Monica Sabater-Vilar and Roel F. M. Maas and Hendrik De Bosschere and Richard V Ducatelle and Johanna Fink-Gremmels}, journal={Mycopathologia}, year={2004}, volume={158}, pages={419-426} }