Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

@article{Halushka1999PatternsOS,
  title={Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis},
  author={Marc K. Halushka and Jian-Bing Fan and Kimberly Bentley and Linda Hsie and Naiping Shen and Alan B. Weder and Richard S. Cooper and Robert J. Lipshutz and Aravinda Chakravarti},
  journal={Nature Genetics},
  year={1999},
  volume={22},
  pages={239-247}
}
Sequence variation in human genes is largely confined to single-nucleotide polymorphisms (SNPs) and is valuable in tests of association with common diseases and pharmacogenetic traits. We performed a systematic and comprehensive survey of molecular variation to assess the nature, pattern and frequency of SNPs in 75 candidate human genes for blood-pressure homeostasis and hypertension. We assayed 28 Mb (190 kb in 148 alleles) of genomic sequence, comprising the 5´ and 3´ untranslated regions… Expand
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