Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy.

@article{Rousseau2001PatternsOR,
  title={Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy.},
  author={Marcela Rousseau and Laurence Vergne and Brigitte Mont{\`e}s and Martine Peeters and J. Reynes and Eric Delaporte and Michel Segondy},
  journal={Journal of acquired immune deficiency syndromes},
  year={2001},
  volume={26 1},
  pages={36-43}
}
Resistance-mutation patterns in the reverse transcriptase (RT) and protease genes of HIV-1 were analyzed in 22 patients who had been extensively pretreated and who failed to respond to highly active antiretroviral therapy (HAART). The number of mutations ranged from 8 to 19 (median, 13): 4 to 12 (median, 6) mutations in the RT gene, and 4 to 8 (median, 7) mutations in the protease gene. In the RT gene, the most frequent resistance mutations were found at codons 215 (100%), 41 (95%), 67 (91… CONTINUE READING
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