Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab.

@article{Pope2011PatternsOP,
  title={Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab.},
  author={Whitney B. Pope and Qing Xia and Virginia E Paton and Ashim Das and Julie Hambleton and Hyo Jung Kim and Jing Huo and Martin Brown and Jonathan G. Goldin and Timothy C. Cloughesy},
  journal={Neurology},
  year={2011},
  volume={76 5},
  pages={432-7}
}
OBJECTIVE We evaluated patterns of tumor progression in patients with recurrent glioblastoma who were treated with bevacizumab (BEV) alone or in combination with irinotecan (CPT-11) while participating in the BRAIN study. METHODS An independent neuroradiologist reviewed MRI scans at baseline and progression in patients who received BEV (n = 85) or BEV+CPT-11 (n = 82) while on BRAIN. Tumor patterns were scored as local, distant, diffuse, or multifocal. Median progression-free survival (PFS… CONTINUE READING

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