Patterns of polymorphism and linkage disequilibrium for cystic fibrosis.

  title={Patterns of polymorphism and linkage disequilibrium for cystic fibrosis.},
  author={Xavier Estivill and Peter J. Scambler and Brandon J. Wainwright and Katherine Hawley and Paul Frederick and Marianne Schwartz and Montserrat Baiget and Juha Kere and R. Williamson and Martin Farrall},
  volume={1 3},
Four polymorphic markers that map within 80 kb of an HTF island which is genetically very close to the cystic fibrosis locus have been identified. We have analyzed the linkage disequilibrium between each of these markers and the cystic fibrosis mutation in 89 families from four European countries, Denmark, Finland, Spain, and Great Britain. Strong linkage disequilibrium between three polymorphic sites and cystic fibrosis was observed. The markers on the J3.11 (D7S8) side of the HTF island show… CONTINUE READING