Patterns of myocardial fibrosis.

  title={Patterns of myocardial fibrosis.},
  author={Karl T. Weber and Ruth Pick and Jorge E. Jalil and Joseph S Janicki and E P Carroll},
  journal={Journal of molecular and cellular cardiology},
  volume={21 Suppl 5},
The interstitium of the myocardium is composed of predominantly type I collagen; type III collagen is present to a lesser extent. The fibrillar collagens serve as tethers between muscle cells, muscle fibers, and blood vessels while also providing a scaffolding that supports the muscular and vascular compartments. In pressure overload hypertrophy, a continuous structural remodeling of the fibrillar collagen matrix is seen. What is initially an adaptive process that enhances tensile strength can… CONTINUE READING


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