Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter

@article{Wang2010PatternsOM,
  title={Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter},
  author={Wang-Xia Wang and Qingwei Huang and Yanling Hu and Arnold J. Stromberg and Peter T. Nelson},
  journal={Acta Neuropathologica},
  year={2010},
  volume={121},
  pages={193-205}
}
MicroRNA (miRNA) expression was assessed in human cerebral cortical gray matter (GM) and white matter (WM) in order to provide the first insights into the difference between GM and WM miRNA repertoires across a range of Alzheimer's disease (AD) pathology. RNA was isolated separately from GM and WM portions of superior and middle temporal cerebral cortex (N = 10 elderly females, postmortem interval < 4 h). miRNA profiling experiments were performed using state-of-the-art Exiqon© LNA-microarrays… CONTINUE READING
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