Patterns of imatinib resistance mutation analysis in chronic myeloid leukemia (CML) patients on imatinib at the time of loss of response to the drug in Asian Indian subjects.

@article{Prabhash2009PatternsOI,
  title={Patterns of imatinib resistance mutation analysis in chronic myeloid leukemia (CML) patients on imatinib at the time of loss of response to the drug in Asian Indian subjects.},
  author={Kumar Prabhash and Tushar Vora and Nikhil S. Ghadyalpatil and Bharath Rangarajan and Sachin Sharatchandra Hingmire and Hari Vinayak Menon and Parmanand N Jain and Purna Arun Kurkure and Purvish Mahendra Parikh},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 15_suppl},
  pages={7079}
}
7079 Background: The treatment of (CML) has undergone major changes in the past decade with the introduction of tyrosine kinase inhibitors (TKI). However the initial enthusiasm is waning with increasing recognition of drug resistance. There is an urgent need to identify the types of receptor mutations which lead to drug resistance and their significance in salvage therapy. METHODS We identified 17 males and 8 female patients with median age 40 yrs (range 9-55 years) with CML who were on… CONTINUE READING
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