Patterns of failure with increasing intensification of induction chemotherapy for acute myeloid leukaemia

@article{Matthews2001PatternsOF,
  title={Patterns of failure with increasing intensification of induction chemotherapy for acute myeloid leukaemia},
  author={Jane P. Matthews and James F. Bishop and Graham A. R. Young and Surender K Juneja and Ray M. Lowenthal and O. Margaret Garson and Ralph Cobcroft and Anthony J. Dodds and Arno Enno and E. A. Gillett and Reichenspurner Hermann and Douglas Edgar Joshua and David D. F. Ma and Jeffrey Szer and Kerry McDonald Taylor and Max M Wolf and Km Bradstock},
  journal={British Journal of Haematology},
  year={2001},
  volume={113}
}
Patterns of failure were studied in two consecutive randomized trials of intensified induction therapy carried out by the Australian Leukaemia Study Group (ALSG) between 1984 and 1991 to determine the impact of dose intensification. Patients received standard dose cytarabine and daunorubicin (7‐3), 7‐3 plus etoposide (7‐3‐7) or 7‐3 plus high‐dose cytarabine (HIDAC‐3‐7) chemotherapy. Patients with FAB M3 morphology were excluded. Time to failure (TTF) was defined as the time from randomization… 

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The prevalent predicament of relapsed acute myeloid leukemia.

  • J. Szer
  • Medicine, Biology
    Hematology. American Society of Hematology. Education Program
  • 2012
All patients with relapsed AML should be considered for an appropriate clinical trial and a decision made about the appropriateness of intensive therapy and whether a potentially curative allogeneic stem cell transplantation (allo-SCT) is possible.

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