Patterns of engraftment in different strains of immunodeficient mice reconstituted with human peripheral blood lymphocytes.

Abstract

BACKGROUND Models of immunodeficient mice reconstituted with a competent human immune system would represent an invaluable tool for the study of transplantation immunobiology allergy, autoimmunity, and infectious diseases. Severe combined immune deficiency (scid) mice can be successfully reconstituted with human peripheral blood lymphocytes (PBLs), but… (More)

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