Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.

@article{Kwun2012PatternsOD,
  title={Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.},
  author={Jean Kwun and Byung Chul Oh and Adriana C Gibby and Ravi Ruhil and Vi Thanh Lu and Dong W. Kim and Eugenia K. Page and Ozlem Pinar Bulut and Ming Qing Song and Alton Brad Farris and Allan D. Kirk and Stuart J Knechtle and Neal N. Iwakoshi},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 10},
  pages={
          2641-51
        }
}
Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody-mediated mechanisms during CR are poorly understood due to lack of proper animal models and tools. In a clinical setting, we previously demonstrated that induction therapy by lymphocyte depletion, using alemtuzumab (anti-human CD52), is associated with an increased incidence of serum alloantibody, C4d deposition and… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

The immunological function of CD52 and its targeting in organ transplantation

  • Inflammation Research
  • 2017
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Lymphodepletional strategies in transplantation.

  • Cold Spring Harbor perspectives in medicine
  • 2013
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2017
VIEW 1 EXCERPT

Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS

Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2016
VIEW 1 EXCERPT
CITES METHODS

HMGB1 is involved in chronic rejection of cardiac allograft via promoting inflammatory-like mDCs.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2014
VIEW 1 EXCERPT

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Elimination of the immunogenicity of therapeutic antibodies.

  • Journal of immunology
  • 1999
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

Y Chung, S Tanaka, F Chu
  • Nat Med
  • 2011

Similar Papers

Loading similar papers…