Patterns of cortical reorganization in complex regional pain syndrome

@article{Maihfner2003PatternsOC,
  title={Patterns of cortical reorganization in complex regional pain syndrome},
  author={Christian Maih{\"o}fner and Hermann O. Handwerker and Bernhard Neundörfer and Frank Birklein},
  journal={Neurology},
  year={2003},
  volume={61},
  pages={1707 - 1715}
}
Objective: To use magnetoencephalography to assess possible cortical reorganization in the primary somatosensory cortex (S1) of patients with complex regional pain syndrome (CRPS). Background: Patterns of pain and sensory symptoms in CRPS may indicate plastic changes of the CNS. Methods: Magnetic source imaging was used to explore changes in the cortical representation of digits (D) 1 and 5 in relation to the lower lip on the unaffected and affected CRPS side in 12 patients. Results: The… Expand

Paper Mentions

Interventional Clinical Trial
SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms… Expand
ConditionsAmplified Musculoskeletal Pain Syndrome (AMPS), Chronic Widespread Pain, Complex Regional Pain Syndrome (CRPS), (+3 more)
InterventionBehavioral
Interventional Clinical Trial
Medical functional imagery seems to demonstrate that patients suffering from complex regional pain syndrome (CRPS) have cortical modifications that alter their motor (or mental) imagery… Expand
ConditionsComplex Regional Pain Syndromes, Healthy, Musculoskeletal Pain Disorder
InterventionDiagnostic Test
Interventional Clinical Trial
This study evaluates the effectiveness of imagery motor on phantom pain and amputation process  
ConditionsAmputees
InterventionOther
Cortical reorganization during recovery from complex regional pain syndrome
TLDR
Changes of the somatotopic map within the S1 cortex may depend on CRPS pain and its recovery, and these changes are unclear how these S1 changes develop following successful therapy. Expand
Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome
TLDR
It is concluded that patterns of cortical reorganization in SI and SII seem to parallel impaired tactile discrimination and the amount of reorganization and tactile impairment appeared to be linked to characteristics of CRPS pain. Expand
Investigations on maladaptive plasticity in the sensorimotor cortex of unilateral upper limb CRPS I patients.
TLDR
This study is the first to gather behavioral, neurophysiologic and imaging measurements for one patient cohort and it enables a comprehensive view of collapsed associations of function and representation focused on the hemisphere contralateral to the affected hand. Expand
TMS motor cortical brain mapping in patients with complex regional pain syndrome type I
TLDR
The presence of pain and other CRPS symptoms may induce lasting changes in motor cortical plasticity, as it also does in the sensory cortex. Expand
Cortical reorganization in primary somatosensory cortex in patients with unilateral chronic pain.
TLDR
The present results indicate that cortical reorganization occurs in chronic neuropathic pain patients even without peripheral nerve damage, and it is possible that corticalorganization is related to chronic pain, regardless of its etiology. Expand
Motor cortex dysfunction in complex regional pain syndrome
TLDR
Abnormal motor cortex reactivity may be linked with motor dysfunction of the affected hand in CRPS, and continuous pain inCRPS is associated with attenuated motor cortex reactsivity. Expand
The motor system shows adaptive changes in complex regional pain syndrome.
TLDR
The results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS. Expand
Mislocalization of tactile stimulation in patients with complex regional pain syndrome
TLDR
The occurrence of mislocalizations was correlated with a detailed psychophysical examination in which sensory, motor and autonomic symptoms were assessed and support the concept of pain–induced reorganization in the somatosensory system of CRPS patients. Expand
Preserved cortical maps of the body in Complex Regional Pain Syndrome
TLDR
Given that S1 representations are largely preserved in CPRS patients, it is compelling to reconsider not only the cortical mechanisms that underlie the disorder, but also the rationale for interventions that aim to restore somatotopic representations. Expand
Functional imaging of allodynia in complex regional pain syndrome
TLDR
The pattern of cortical deactivation during allodynia may hint at a shift of activation from tonically active sensory systems, like visual and vestibular cortices, into somatosensory-related brain areas. Expand
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