Patterns of clinical response and plasma dopa levels in Parkinson's disease.

@article{Tolosa1975PatternsOC,
  title={Patterns of clinical response and plasma dopa levels in Parkinson's disease.},
  author={Eduardo Tolosa and W. E. Martin and Hai Cohen and Raymond Leonard Jacobson},
  journal={Neurology},
  year={1975},
  volume={25 2},
  pages={177-83}
}
Serial determinations of plasma dihydroxyphenylalanine (dopa) in 16 Parkinson's disease patients receiving levodopa showed a negative correlation between plasma dopa levels and disability scores among patients who exhibited daily fluctuations of signs and symptoms. This suggests that the amount of levodopa delivered to the brain from the periphery is of major importance in the production of the "on-off" phenomenon. A close relationship between plasma dopa levels and abnormal involuntary… CONTINUE READING

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