Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma

  title={Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma},
  author={Cyril Dalmasso and Wassila Carpentier and Catherine Guettier and Sophie Camilleri-Bro{\"e}t and Wyllians Vendramini Borelli and Ced{\'a}lia Rosane Campos dos Santos and Denis Castaing and Jean-Charles Duclos-Vall{\'e}e and Philippe Bro{\"e}t},
  booktitle={BMC Cancer},
Intrahepatic cholangiocarcinomas (ICC) are relatively rare malignant tumors associated with a poor prognosis. Recent studies using genome-wide sequencing technologies have mainly focused on identifying new driver mutations. There is nevertheless a need to investigate the spectrum of copy number aberrations in order to identify potential target genes in the altered chromosomal regions. The aim of this study was to characterize the patterns of chromosomal copy-number alterations (CNAs) in ICC. 53… CONTINUE READING
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