Patterns of autobiographical memory loss in dementia

  title={Patterns of autobiographical memory loss in dementia},
  author={Craig E. Hou and Bruce L Miller and Joel H. Kramer},
  journal={International Journal of Geriatric Psychiatry},
Several studies have found impaired recall of remote autobiographical memories relative to recent memories in semantic dementia (SD), a pattern opposite to that in Alzheimer's disease (AD). 

Autobiographical memory deficits in Alzheimer's disease.

Episodic autobiographical memories, especially the richness of details, were impaired early in the course of Alzheimer's disease or even in the preclinical phase, while semantic memories were spared until moderate stages, indicating a dissociation between both memory systems.

Autobiographical Memory Performance in Alzheimer's Disease Depends on Retrieval Frequency.

It is suggested that more frequently retrieved autobiographical memories generally become more independent of the hippocampal complex and might thus be better protected against early hippocampal damage related to AD.

Autobiographical memory in mild cognitive impairment and Alzheimer's disease: A comparison between the Levine and Kopelman interview methodologies

Differences between the two interview methods were found to have a significant impact on the pattern of findings; fewer epochs in the AMI brought out the temporal gradient, and fewer memories per epoch in the AI diminished it.

Autobiographical memory in semantic dementia: A longitudinal fMRI study

Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer’s disease

As the largest study of ABM in FTD to date, these findings emphasise the differential impairment of recent ABM contextual details contingent on the underlying disease pathology and point towards the importance of investigating the constituent elements of emotion processing and strategic retrieval processes as potential variables mediating recent episodic ABM retrieval.



Autobiographical memory in advanced multiple sclerosis: Assessment of episodic and personal semantic memory across three time spans

Memory for episodic autobiographical incidents was more affected than for personal semantic information; a temporal gradient typical of some dementing conditions but not before demonstrated in MS, was also observed with memory for more recent events showing a significant decline.

Semantic-Episodic Memory Interactions in Semantic Dementia: Implications for Retrograde Memory Function

Semantic dementia refers to a multi-modal loss of semantic knowledge, resulting from degeneration of the anterior temporal neocortex. Loss of information is not absolute. We have previously

Different Patterns of Autobiographical Memory Loss in Semantic Dementia and Medial Temporal Lobe Amnesia: a Challenge to Consolidation Theory.

It is proposed that the hippocampal complex plays a permanent role in the storage and retrieval of autobiographical episodes and that autobiographical significance may affect semantic representations.

Recollection-based memory in frontotemporal dementia: implications for theories of long-term memory.

Although some patients showed impaired source and associative memory, many performed as well as control participants and the role of frontal lobe systems in recollection-based memory was highlighted, providing further compelling evidence in favour of the multiple input model of long-term memory.

A positron emission tomography (PET) study of autobiographical memory retrieval.

It is proposed that this left frontal lobe activation reflects the operation of control processes that modulate the construction of AMs in posterior neocortical networks.

Neuroimaging studies of autobiographical event memory.

  • E. Maguire
  • Psychology, Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2001
The overall pattern across studies is of medial and left-lateralized activations associated with retrieval of autobiographical event memories, and it seems that the medial frontal cortex and left hippocampus in particular are responsive to such memories.