Patterns of antibody recognition of selected conserved amino acid sequences from the HIV envelope in sera from different stages of HIV infection.

@article{Shafferman1989PatternsOA,
  title={Patterns of antibody recognition of selected conserved amino acid sequences from the HIV envelope in sera from different stages of HIV infection.},
  author={A Shafferman and Jeffrey L. Lennox and Haim Grosfeld and Jerry Sadoff and Robert R Redfield and Donald S. Burke},
  journal={AIDS research and human retroviruses},
  year={1989},
  volume={5 1},
  pages={33-9}
}
A total of six amino acid sequences encoded in conserved regions of the HIV-env (three from gp120 and three from gp41) were selected as potential antigenic domains. These sequences (11-20 amino acids) were fused to the NH2 terminus of beta-galactosidase by recombinant DNA techniques, and the purified chimeric proteins were used to titer (by immunodots) 75… CONTINUE READING