Patterns of Pulmonary Complications Associated with Sirolimus

  title={Patterns of Pulmonary Complications Associated with Sirolimus},
  author={Prashant N. Chhajed and Michael Dickenmann and Lukas Bubendorf and Michael Mayr and J. U. Steiger and Michael Tamm},
  pages={367 - 374}
Sirolimus inhibits human fibroblast cell proliferation in cell cultures from transbronchial biopsies of lung transplant recipients. However, a few cases of interstitial pneumonitis and bronchiolitis obliterans organizing pneumonia have been recently described in solid organ transplant recipients, including a fatality in a heart transplant recipient. We studied the patterns of pulmonary adverse effects associated with sirolimus in 4 renal transplant recipients who developed pulmonary opacities… 

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