Patterns of Positive Selection in Six Mammalian Genomes

@article{Kosiol2008PatternsOP,
  title={Patterns of Positive Selection in Six Mammalian Genomes},
  author={Carolin Kosiol and Tom{\'a}{\vs} Vinař and Rute R da Fonseca and Melissa J. Hubisz and Carlos Daniel Bustamante and R. Nielsen and Adam Siepel},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={3179 - 3180}
}
Genome-wide scans for positively selected genes (PSGs) in mammals have provided insight into the dynamics of genome evolution, the genetic basis of differences between species, and the functions of individual genes. However, previous scans have been limited in power and accuracy owing to small numbers of available genomes. Here we present the most comprehensive examination of mammalian PSGs to date, using the six high-coverage genome assemblies now available for eutherian mammals. The increased… CONTINUE READING

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