Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma.

@article{Thompson2017PatternsOP,
  title={Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma.},
  author={E. Dale Thompson and Marianna L. Zahurak and Adrian Murphy and Toby C Cornish and Nathan S. Cuka and Eihab Abdelfatah and Stephen Chi-Tin Yang and Mark C. Duncan and Nita Ahuja and Janis M Taube and Robert Albert Anders and Ronan Joseph Kelly},
  journal={Gut},
  year={2017},
  volume={66 5},
  pages={
          794-801
        }
}
OBJECTIVE Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells and the relationship of both factors to patient survival. DESIGN Thirty-four resections of primary invasive G/GEJ were stained by immunohistochemistry for PD-L1 and CD8 and by DNA in situ hybridisation for… CONTINUE READING
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