Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals

@article{Liu2006PatternsOG,
  title={Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals},
  author={Jianwen Liu and Joanne Marie Lewohl and R. Adron Harris and Vishwanath R. Iyer and Peter Ronald Dodd and Patrick K. Randall and R Dayne Mayfield},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={1574-1582}
}
Alcohol dependence is characterized by tolerance, physical dependence, and craving. The neuroadaptations underlying these effects of chronic alcohol abuse are likely due to altered gene expression. Previous gene expression studies using human post-mortem brain demonstrated that several gene families were altered by alcohol abuse. However, most of these changes in gene expression were small. It is not clear if gene expression profiles have sufficient power to discriminate control from alcoholic… CONTINUE READING
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