Patterns of Excitation of Thalamic Neurones by Amino-acids and by Acetylcholine

@article{Mclennan1968PatternsOE,
  title={Patterns of Excitation of Thalamic Neurones by Amino-acids and by Acetylcholine},
  author={H. Mclennan and Ronald D. Huffman and Kenneth C. Marshall},
  journal={Nature},
  year={1968},
  volume={219},
  pages={387-388}
}
SINCE the demonstration of the excitatory action of the dicarboxylic amino-acids on spinal neurones1,2, similar observations have been made on many other neuronal types within the central nervous system, and involving a considerable number of analogues, particularly of glutamic acid, as stimulating agents3. It is widely accepted that most central neurones are affected by these substances, and the implication is that they all act on the same receptive sites of the affected cell. In contrast… 
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It appears that all or almost all neurons of the central nervous system can be depolarized and excited by glutamate or aspartate introduced into their immediate extracellular environments.

Excitation of mammalian central neurones by acidic amino acids.

The pharmacology of thalamic and geniculate neurons.

  • J. Phillis
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    International review of neurobiology
  • 1971

Differential sensitivity of selected brain areas to excitatory amino acids

Subtypes of Glutamate Receptors

The amino acid, L-glutamate, is now generally accepted as the mediator of fast excitatory neurotransmission in the mammalian brain and spinal cord and raised the possibility of glutamate as a neurotransmitter.

The use of transmitter antagonists in microelectrophoretic investigations of central synaptic transmission

This paper is concerned with pharmacological interference with transmitter action and discusses micro-electrophoretic methods, since investigations in which selective antagonists of a particular transmitter process are administered close to synapses may be useful in establishing the nature of the transmitter and may provide information of therapeutic significance.

Inhibitions of long duration in the cerebral cortex. A quantitative difference between excitatory amino acids

The inhibition produced by a given stimulation was generally considerably longer in neurones activated by glutamate than in the same cells excited by homocysteate, and this difference was most marked in cells lying in layers II and V of the cortex.

Unit study in cat claustrum of the effects of iontophoretic neurotransmitters and correlations with the effects of activation of some afferent pathways.

An analysis was made of the time-course of excitatory and inhibitory responses on the basis of the mean firing rate variations during and after ACh and DA release, which suggested ACh could be supposed to be the transmitter of most of the inhibitory terminals of these sensitive afferences to the claustrum.

Actions of amino acids and convulsants on bulbar reticular neurones

A comparison of the results with those obtained in the spinal cord provides some evidence that glycine may be an inhibitory transmitter substance released on bulbar reticular neurones.
...

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