Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status

@article{Mudali2006PatternsOE,
  title={Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status},
  author={Shiyama V. Mudali and Baojin Fu and Sindhu S. Lakkur and Mingde Luo and Erlinda E. Embuscado and Christine A Iacobuzio-Donahue},
  journal={Clinical & Experimental Metastasis},
  year={2006},
  volume={23},
  pages={357-365}
}
EphA2 is a transmembrane receptor tyrosine kinase that functions in the regulation of cell growth, survival, angiogenesis, and migration and EphA2 targeting has been proposed as a novel therapeutic strategy for neoplasms that overexpress this protein. EphA2 overexpression has been correlated with increased invasive and metastatic ability in pancreatic cancer cell lines. However, the patterns of EphA2 expression in human pancreatic cancers and associated metastases is unknown, as are the… CONTINUE READING

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